Discovery of new acetylcholinesterase inhibitors for Alzheimer's disease: virtual screening and in vitro characterisation

• Główni autorzy: Benoit David (Autor), Pascal Schneider (Autor), Philipp Schäfer (Autor), Jörg Pietruszka (Autor), Holger Gohlke (Autor)
• Format: Książka
• Wydane: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

For more than two decades, the development of potent acetylcholinesterase (AChE) inhibitors has been an ongoing task to treat dementia associated with Alzheimer's disease and improve the pharmacokinetic properties of existing drugs. In the present study, we used three docking-based virtual scre...