Discovery of new acetylcholinesterase inhibitors for Alzheimer's disease: virtual screening and in vitro characterisation

• मुख्य लेखकों: Benoit David (लेखक), Pascal Schneider (लेखक), Philipp Schäfer (लेखक), Jörg Pietruszka (लेखक), Holger Gohlke (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

For more than two decades, the development of potent acetylcholinesterase (AChE) inhibitors has been an ongoing task to treat dementia associated with Alzheimer's disease and improve the pharmacokinetic properties of existing drugs. In the present study, we used three docking-based virtual scre...