Age-dependent Hepatic UDP-glucuronosyltransferase Gene Expression and Activity in Children

• Main Authors: Elizabeth Neumann (Author), Huma Mehboob (Author), Jacqueline Ramírez (Author), Snezana Mirkov (Author), Min Zhang (Author), Wanqing Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTUDP-glucuronosyltransferases (UGTs) are important phase II drug metabolism enzymes. The aim of this study was to explore the relationship between age and changes in mRNA expression and activity of major human hepatic UGTs, as well as to understand the potential regulatory mechanism underlyin...