Ball-Milling Preparation of the Drug-Drug Solid Form of Pioglitazone-Rosuvastatin at Different Molar Ratios: Characterization and Intrinsic Dissolution Rates Evaluation

Ball-Milling Preparation of the Drug-Drug Solid Form of Pioglitazone-Rosuvastatin at Different Molar Ratios: Characterization and Intrinsic Dissolution Rates Evaluation

Ball-milling using neat grinding (NG) or liquid-assisted grinding (LAG) by varying the polarity of the solvents allowed access to various drug-drug solid forms of pioglitazone hydrochloride (PGZ·HCl) and rosuvastatin calcium (RSV). Using NG, the coamorphous form was formed from the reaction of piogl...

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Main Authors: M. Fernanda Muñoz Tecocoatzi (Author), José C. Páez-Franco (Author), Kenneth Rubio-Carrasco (Author), Alejandra Núñez-Pineda (Author), Alejandro Dorazco-González (Author), Inés Fuentes-Noriega (Author), Alfredo R. Vilchis-Néstor (Author), Lilian I. Olvera (Author), David Morales-Morales (Author), Juan Manuel Germán-Acacio (Author)
Format: Book
Published: MDPI AG, 2023-02-01T00:00:00Z.
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