Myelomonocytic leukaemia (JMML) in a child with intellectual disability and chromosome 4q deletion

• Main Authors: Harsha Prasada Lashkari (Author), Naga Venkata Sirisha Andey (Author), Nanda Kumar (Author), Katta M. Girisha (Author)
• Format: Book
• Published: Elsevier, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

JMML is a rare aggressive type of leukaemia seen in children. It is often seen with syndromes such as Noonan, and neurofibromatosis type 1. Rarely it can be a sporadic event. The pathogenesis of myeloproliferation in this condition is due to the activation of the MAPK-RAS pathway. We here report an...