Precision dosing of intravenous busulfan in pediatric hematopoietic stem cell transplantation: Results from a multicenter population pharmacokinetic study

• Main Authors: Khalil Ben Hassine (Author), Tiago Nava (Author), Yves Théoret (Author), Christa E. Nath (Author), Youssef Daali (Author), Nastya Kassir (Author), Victor Lewis (Author), Robbert G. M. Bredius (Author), Peter J. Shaw (Author), Henrique Bittencourt (Author), Maja Krajinovic (Author), Chakradhara Rao Satyanarayana Uppugunduri (Author), Marc Ansari (Author)
• Format: Book
• Published: Wiley, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Busulfan (Bu) is a common component of conditioning regimens before hematopoietic stem cell transplantation (HSCT) and is known for high interpatient pharmacokinetic (PK) variability. This study aimed to develop and externally validate a multicentric, population PK (PopPK) model for intrave...