Identification of a Fragment-Based Scaffold that Inhibits the Glycosyltransferase WaaG from Escherichia coli

• Main Authors: Claudio Muheim (Author), Amin Bakali (Author), Olof Engström (Author), Åke Wieslander (Author), Daniel O. Daley (Author), Göran Widmalm (Author)
• Format: Book
• Published: MDPI AG, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

WaaG is a glycosyltransferase that is involved in the biosynthesis of lipopolysaccharide in Gram-negative bacteria. Inhibitors of WaaG are highly sought after as they could be used to inhibit the biosynthesis of the core region of lipopolysaccharide, which would improve the uptake of antibiotics. He...