Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis.

• Main Authors: Louise E Kerry (Author), Elaine E Pegg (Author), Donald P Cameron (Author), James Budzak (Author), Gretchen Poortinga (Author), Katherine M Hannan (Author), Ross D Hannan (Author), Gloria Rudenko (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trypanosoma brucei relies on an essential Variant Surface Glycoprotein (VSG) coat for survival in the mammalian bloodstream. High VSG expression within an expression site body (ESB) is mediated by RNA polymerase I (Pol I), which in other eukaryotes exclusively transcribes ribosomal RNA genes (rDNA)....