Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP5+, Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation

• Main Authors: John Mark Cline (Author), Greg Dugan (Author), John Daniel Bourland (Author), Donna L. Perry (Author), Joel D. Stitzel (Author), Ashley A. Weaver (Author), Chen Jiang (Author), Artak Tovmasyan (Author), Kouros Owzar (Author), Ivan Spasojevic (Author), Ines Batinic-Haberle (Author), Zeljko Vujaskovic (Author)
• Format: Book
• Published: MDPI AG, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Radiation injury to the lung is the result of acute and chronic free radical formation, and there are currently few effective means of mitigating such injury. Studies in rodents indicate that superoxide dismutase mimetics may be effective in this regard; however, studies in humans or large animals a...