Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk

• Main Authors: Melissa M. Clemens (Author), Stefanie Kennon-McGill (Author), Joel H. Vazquez (Author), Owen W. Stephens (Author), Erich A. Peterson (Author), Donald J. Johann (Author), Felicia D. Allard (Author), Eric U. Yee (Author), Sandra S. McCullough (Author), Laura P. James (Author), Brian N. Finck (Author), Mitchell R. McGill (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously demonstrated that endogenous phosphatidic acid (PA) promotes liver regeneration after acetaminophen (APAP) hepatotoxicity. Here, we hypothesized that exogenous PA is also beneficial. To test that, we treated mice with a toxic APAP dose at 0 h, followed by PA or vehicle (Veh) post-treat...