Peripherally Administered Y2-Receptor Antagonist BIIE0246 Prevents Diet-Induced Obesity in Mice With Excess Neuropeptide Y, but Enhances Obesity in Control Mice

• Κύριοι συγγραφείς: Liisa Ailanen (Συγγραφέας), Laura H. Vähätalo (Συγγραφέας), Henriikka Salomäki-Myftari (Συγγραφέας), Satu Mäkelä (Συγγραφέας), Wendy Orpana (Συγγραφέας), Suvi T. Ruohonen (Συγγραφέας), Eriika Savontaus (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Frontiers Media S.A., 2018-04-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Neuropeptide Y (NPY) plays an important role in the regulation of energy homeostasis in the level of central and sympathetic nervous systems (SNSs). Genetic silencing of peripheral Y2-receptors have anti-obesity effects, but it is not known whether pharmacological blocking of peripheral Y2-receptors...