Simultaneous Determination of Docetaxel and Celecoxib in Porous Microparticles and Rat Plasma by Liquid-Liquid Extraction and HPLC with UV Detection: in vitro and in vivo Validation and Application

• 主要な著者: Elham Ziaei (著者), Jaber Emami (著者), Moloud Kazemi (著者), Mahboubeh Rezazadeh (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2020-08-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Purpose: A simple, rapid, sensitive, and reliable HPLC method with UV detection was developed and validated for simultaneous quantitation of docetaxel and celecoxib and paclitaxel for dissolution characterization and pharmacokinetic studies. Methods: The HPLC assay was performed isocratically on a r...