Predicting pharmacodynamic effects through early drug discovery with artificial intelligence-physiologically based pharmacokinetic (AI-PBPK) modelling

• Main Authors: Keheng Wu (Author), Xue Li (Author), Zhou Zhou (Author), Youni Zhao (Author), Mei Su (Author), Zhuo Cheng (Author), Xinyi Wu (Author), Zhijun Huang (Author), Xiong Jin (Author), Jingxi Li (Author), Mengjun Zhang (Author), Jack Liu (Author), Bo Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A mechanism-based pharmacokinetic/pharmacodynamic (PK/PD) model links the concentration-time profile of a drug with its therapeutic effects based on the underlying biological or physiological processes. Clinical endpoints play a pivotal role in drug development. Despite the substantial time and effo...