Therapeutic Applications and Challenges of a Widely Used Antifolate Drug

• Main Authors: Rafał Makuch (Author), Alicja Chrościcka (Author), Kamil Gała (Author), Andrzej Czajka (Author), Paweł Lenard (Author), Adam Kucharski (Author), Sara Michalska (Author), Konrad Pilarski (Author), Martyna Dewicka (Author), Alicja Maria Wawrzyniak (Author)
• Format: Book
• Published: Nicolaus Copernicus University in Toruń, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction and purpose: Methotrexate (MTX) is an antifolate metabolite that interferes with the synthesis and repair of DNA and with cell replication. It has anti-inflammatory and immunomodulatory properties and was first used in 1951 for the treatment of RA and psoriasis. Methotrexate (4-amino-10...