Hyperforin, an anti-inflammatory constituent from St. John's wort, inhibits microsomal prostaglandin E2 synthase-1 and suppresses prostaglandin E2 formation in vivo

• Main Authors: Andreas eKoeberle (Author), Antonietta eRossi (Author), Julia eBauer (Author), Friederike eDehm (Author), Luisella eVerotta (Author), Hinnak eNorthoff (Author), Lidia eSautebin (Author), Oliver eWerz (Author)
• Format: Book
• Published: Frontiers Media S.A., 2011-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The acylphloroglucinol hyperforin (Hyp) from St. John's wort possesses anti-inflammatory and anti-carcinogenic properties which were ascribed among others to the inhibition of 5-lipoxygenase. Here, we investigated whether Hyp also interferes with prostanoid generation in biological systems, par...