TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway

• Main Authors: Sarbani Ghoshal (Author), Qingzhang Zhu (Author), Alice Asteian (Author), Hua Lin (Author), Haifei Xu (Author), Glen Ernst (Author), James C. Barrow (Author), Baoji Xu (Author), Michael D. Cameron (Author), Theodore M. Kamenecka (Author), Anutosh Chakraborty (Author)
• Format: Book
• Published: Elsevier, 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Obesity and type 2 diabetes (T2D) lead to various life-threatening diseases such as coronary heart disease, stroke, osteoarthritis, asthma, and neurodegeneration. Therefore, extensive research is ongoing to identify novel pathways that can be targeted in obesity/T2D. Deletion of the inosi...