Computational design of newly engineered DARPins as HER2 receptor inhibitors for breast cancer treatment

• Autori principali: Maryam Beheshti Isfahani (Autore), Karim Mahnam (Autore), Hooria Seyedhosseini-Ghaheh (Autore), Hamid Mir Mohammad Sadeghi (Autore), Hossein Khanahmad (Autore), Vajihe Akbari (Autore), Jaleh Varshosaz (Autore)
• Natura: Libro
• Pubblicazione: Wolters Kluwer Medknow Publications, 2023-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Background and purpose: Human epidermal growth factor receptor 2 (HER2) is overexpressed in approximately 25% of breast cancer patients; therefore, its inhibition is a therapeutic target in cancer treatment. Experimental approach: In this study, two new variants of designed ankyrin repeat proteins (...