Computational design of newly engineered DARPins as HER2 receptor inhibitors for breast cancer treatment

• Main Authors: Maryam Beheshti Isfahani (Author), Karim Mahnam (Author), Hooria Seyedhosseini-Ghaheh (Author), Hamid Mir Mohammad Sadeghi (Author), Hossein Khanahmad (Author), Vajihe Akbari (Author), Jaleh Varshosaz (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and purpose: Human epidermal growth factor receptor 2 (HER2) is overexpressed in approximately 25% of breast cancer patients; therefore, its inhibition is a therapeutic target in cancer treatment. Experimental approach: In this study, two new variants of designed ankyrin repeat proteins (...