Identification of novel CYP2D7-2D6 hybrids: non-functional and functional variants

• Main Authors: Andrea Gaedigk (Author), Lazara K M Jaime (Author), Joseph S Bertino, Jr (Author), Anick Bérard (Author), Victoria Pratt (Author), L D Bradford (Author), J S Leeder (Author)
• Format: Book
• Published: Frontiers Media S.A., 2010-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Polymorphic expression of CYP2D6 contributes to the wide range of activity observed for this clinically important drug metabolizing enzyme. In this report we describe novel CYP2D7/2D6 hybrid genes encoding non-functional and functional CYP2D6 protein and a CYP2D7 variant that mimics a CYP2D7/2D6 hyb...