Poloxamer sols endowed with in-situ gelability and mucoadhesion by adding hypromellose and hyaluronan for prolonging corneal retention and drug delivery

• Main Authors: Ling-Chun Chen (Author), Shyr-Yi Lin (Author), Wei-Jie Cheng (Author), Ming-Thau Sheu (Author), Chi-Yun Chung (Author), Chen-Hsuan Hsu (Author), Hong-Liang Lin (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AbstractThe purpose of this study was to develop poloxamer (P407)-based in-situ thermogellable hydrogels with reducing concentration of P407 by adding hypromellose (HPMC) and with enhancing mucoadhesion of resulting hydrogels by adding hyaluronic acid (HA) for prolonging ocular delivery of hydroxypr...