Amino Acids of the Human α 1d-Adrenergic Receptor Involved in Antagonist Binding

• Main Authors: Yuko Nagaoka (Author), Maruf Ahmed (Author), Murad Hossain (Author), Mohiuddin Ahmed Bhuiyan (Author), Masaji Ishiguro (Author), Takashi Nakamura (Author), Masatomo Watanabe (Author), Takafumi Nagatomo (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Computer simulations of the human α 1d-adrenergic receptor (α 1d-AR) based on the crystal structure of rhodopsin have been combined with experimental site-directed mutagenesis to investigate the role of residues in the transmembrane domains in antagonist binding. Our results indicate that the amino...