Macromolecules in polysorbate 80 for injection: an important cause of anaphylactoid reactions

• Main Authors: Yue Li (Author), Jinlian Duan (Author), Heng Xia (Author), Yongkun Li (Author), Bin Shu (Author), Weigang Duan (Author)
• Format: Book
• Published: BMC, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Polysorbate 80 for injection (TW80) is a common excipient used for injection whose macromolecular impurities, including those that cause anaphylactoid reactions, are frequently ignored. The main aim of this study was to prove that the macromolecular impurities in the excipient are an import...