Optimal Design for Estimating Parameters of the 4-Parameter Hill Model

• Egile Nagusiak: Leonid A. Khinkis (Egilea), Laurence Levasseur (Egilea), Hélène Faessel (Egilea), William R. Greco (Egilea)
• Formatua: Liburua
• Argitaratua: SAGE Publishing, 2003-07-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Many drug concentration-effect relationships are described by nonlinear sigmoid models. The 4-parameter Hill model, which belongs to this class, is commonly used. An experimental design is essential to accurately estimate the parameters of the model. In this report we investigate properties of D-opt...