Bergenin ameliorates airway inflammation and remodeling in asthma by activating SIRT1 in macrophages to regulate the NF-κB pathway

• Main Authors: Dan Huang (Author), Chaoqun Sun (Author), Min Chen (Author), Shuyou Bai (Author), Xuanna Zhao (Author), Weiming Wang (Author), Kang Geng (Author), Wenbo Huang (Author), Tingting Zhao (Author), Bin Wu (Author), Guilin Zhang (Author), Dong Wu (Author), Youhua Xu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Airway inflammation and remodeling are critical pathological changes in asthma, and macrophage activation plays a vital role in this process. Sirtuin 1 (SIRT1) reduces airway inflammation by affecting macrophages in asthma. This study aimed to investigate the potential benefit and underlying mechani...