Targeting carbonic anhydrase IX and XII isoforms with small molecule inhibitors and monoclonal antibodies

• Main Authors: Mateusz Kciuk (Author), Adrianna Gielecińska (Author), Somdutt Mujwar (Author), Mariusz Mojzych (Author), Beata Marciniak (Author), Rafał Drozda (Author), Renata Kontek (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Carbonic anhydrases IX and CAXII (CAIX/CAXII) are transmembrane zinc metalloproteins that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide into bicarbonate with a release of the proton. CA, especially CAIX and CAXII isoforms gained the attention of many rese...