Super-sensitive bifunctional nanoprobe: Self-assembly of peptide-driven nanoparticles demonstrating tumor fluorescence imaging and therapy
The development of nanomedicine has recently achieved several breakthroughs in the field of cancer treatment; however, biocompatibility and targeted penetration of these nanomaterials remain as limitations, which lead to serious side effects and significantly narrow the scope of their application. T...
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| Main Authors: | , , , , , , , |
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| Format: | Book |
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Elsevier,
2022-03-01T00:00:00Z.
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| 001 | doaj_4ab1f7769cac4c8f8c64a2d56bdc5a5a | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Han Xiao |e author |
| 700 | 1 | 0 | |a Rui Zhang |e author |
| 700 | 1 | 0 | |a Xiaobo Fan |e author |
| 700 | 1 | 0 | |a Xinglu Jiang |e author |
| 700 | 1 | 0 | |a Mingyuan Zou |e author |
| 700 | 1 | 0 | |a Xuejiao Yan |e author |
| 700 | 1 | 0 | |a Haiping Hao |e author |
| 700 | 1 | 0 | |a Guoqiu Wu |e author |
| 245 | 0 | 0 | |a Super-sensitive bifunctional nanoprobe: Self-assembly of peptide-driven nanoparticles demonstrating tumor fluorescence imaging and therapy |
| 260 | |b Elsevier, |c 2022-03-01T00:00:00Z. | ||
| 500 | |a 2211-3835 | ||
| 500 | |a 10.1016/j.apsb.2021.07.020 | ||
| 520 | |a The development of nanomedicine has recently achieved several breakthroughs in the field of cancer treatment; however, biocompatibility and targeted penetration of these nanomaterials remain as limitations, which lead to serious side effects and significantly narrow the scope of their application. The self-assembly of intermediate filaments with arginine-glycine-aspartate (RGD) peptide (RGD-IFP) was triggered by the hydrophobic cationic molecule 7-amino actinomycin D (7-AAD) to synthesize a bifunctional nanoparticle that could serve as a fluorescent imaging probe to visualize tumor treatment. The designed RGD-IFP peptide possessed the ability to encapsulate 7-AAD molecules through the formation of hydrogen bonds and hydrophobic interactions by a one-step method. This fluorescent nanoprobe with RGD peptide could be targeted for delivery into tumor cells and released in acidic environments such as endosomes/lysosomes, ultimately inducing cytotoxicity by arresting tumor cell cycling with inserted DNA. It is noteworthy that the RGD-IFP/7-AAD nanoprobe tail-vein injection approach demonstrated not only high tumor-targeted imaging potential, but also potent antitumor therapeutic effects in vivo. The proposed strategy may be used in peptide-driven bifunctional nanoparticles for precise imaging and cancer therapy. | ||
| 546 | |a EN | ||
| 690 | |a Nanoprobe | ||
| 690 | |a 7-Amino actinomycin D | ||
| 690 | |a Intermediate filament protein | ||
| 690 | |a Tumor image | ||
| 690 | |a Antitumor therapy | ||
| 690 | |a Integrin αvβ3 | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Acta Pharmaceutica Sinica B, Vol 12, Iss 3, Pp 1473-1486 (2022) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S2211383521002690 | |
| 787 | 0 | |n https://doaj.org/toc/2211-3835 | |
| 856 | 4 | 1 | |u https://doaj.org/article/4ab1f7769cac4c8f8c64a2d56bdc5a5a |z Connect to this object online. |