Modulation of Notch signaling pathway in activated hepatic stellate cells does not ameliorate the outcome of liver fibrosis in carbon tetrachloride and DDC-feeding models

• Main Authors: Dino Šisl (Author), Pavao Planinić (Author), Sanja Novak (Author), Maša Filipović (Author), Darja Flegar (Author), Alan Šućur (Author), Petra Turčić (Author), Nataša Kovačić (Author), Ivo Kalajzić (Author), Danka Grčević (Author), Tomislav Kelava (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundRecent research suggests a possible role of Notch signaling pathway in development of liver fibrosis, but exact cellular and molecular mechanisms are still not well defined. Methods: We modulated Notch signaling in activated hepatic stellate cells/myofibroblasts using the model of inducibl...