Effect of Kupffer cells depletion on ABC phenomenon induced by Kupffer cells-targeted liposomes

• Main Authors: Chaoyang Lai (Author), Cong Li (Author), Mengyang Liu (Author), Qiujun Qiu (Author), Xiang Luo (Author), Xinrong Liu (Author), Ling Hu (Author), Yihui Deng (Author), Yanzhi Song (Author)
• Format: Book
• Published: Elsevier, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Accelerated blood clearance (ABC) phenomenon is common in many PEGylated nanocarriers, whose mechanism has not been completely elucidated yet. In this study, the correlation between Kupffer cells (KCs) and ABC phenomenon has been studied by KCs-targeted liposomes inducing ABC phenomenon and KCs depl...