Phospholipase C Involvement in Activation of the Muscarinic Receptor-Operated Cationic Current in Guinea Pig Ileal Smooth Muscle Cells

• Main Authors: Hiroyuki Okamoto (Author), Toshihiro Unno (Author), Daisuke Arima (Author), Maki Suzuki (Author), Hai-Dun Yan (Author), Hayato Matsuyama (Author), Masakazu Nishimura (Author), Seiichi Komori (Author)
• Format: Book
• Published: Elsevier, 2004-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In guinea pig single ileal smooth muscle cells held under voltage-clamp, the role of phospholipase C (PLC) in activation of the muscarinic receptor-operated cationic current (Icat) was studied. U73122, a PLC inhibitor, prevented the generation of Icat by the muscarinic agonist carbachol. The effect...