Phospholipase C Involvement in Activation of the Muscarinic Receptor-Operated Cationic Current in Guinea Pig Ileal Smooth Muscle Cells

• Hlavní autoři: Hiroyuki Okamoto (Autor), Toshihiro Unno (Autor), Daisuke Arima (Autor), Maki Suzuki (Autor), Hai-Dun Yan (Autor), Hayato Matsuyama (Autor), Masakazu Nishimura (Autor), Seiichi Komori (Autor)
• Médium: Kniha
• Vydáno: Elsevier, 2004-01-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

In guinea pig single ileal smooth muscle cells held under voltage-clamp, the role of phospholipase C (PLC) in activation of the muscarinic receptor-operated cationic current (Icat) was studied. U73122, a PLC inhibitor, prevented the generation of Icat by the muscarinic agonist carbachol. The effect...