TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy

• 主要な著者: Rachel Atkinson (著者), Jacqueline Leung (著者), James Bender (著者), Matthew Kirkcaldie (著者), James Vickers (著者), Anna King (著者)
• フォーマット: 図書
• 出版事項: The Company of Biologists, 2021-02-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Mislocalization of the TAR DNA-binding protein 43 (TDP-43; encoded by TARDBP) from the nucleus to the cytoplasm is a common feature of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). The downstream in vivo cellular effects of thi...