TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy

• Main Authors: Rachel Atkinson (Author), Jacqueline Leung (Author), James Bender (Author), Matthew Kirkcaldie (Author), James Vickers (Author), Anna King (Author)
• Format: Book
• Published: The Company of Biologists, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mislocalization of the TAR DNA-binding protein 43 (TDP-43; encoded by TARDBP) from the nucleus to the cytoplasm is a common feature of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). The downstream in vivo cellular effects of thi...