Potential Neurotoxic Effects of Glioblastoma-Derived Exosomes in Primary Cultures of Cerebellar Neurons via Oxidant Stress and Glutathione Depletion

• Main Authors: Sidika Genc (Author), Manuela Pennisi (Author), Yesim Yeni (Author), Serkan Yildirim (Author), Giuseppe Gattuso (Author), Meric A. Altinoz (Author), Ali Taghizadehghalehjoughi (Author), Ismail Bolat (Author), Aristidis Tsatsakis (Author), Ahmet Hacımüftüoğlu (Author), Luca Falzone (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

High-grade gliomas are the most fatal brain tumors. Grade 4 gliomas are called glioblastoma multiforme (GBM), which are associated with the poorest survival and a 5-year survival rate of less than 4%. Many patients with GBM developed concomitant cognitive dysfunctions and epilepsy. Although the cogn...