Feasibility of cRGD conjugation at 5'-antisense strand of siRNA by phosphodiester linkage extension

• Үндсэн зохиолчид: Xinyang Zhou (Зохиогч), Yufei Pan (Зохиогч), Lijia Yu (Зохиогч), Jing Wu (Зохиогч), Zheng Li (Зохиогч), Huantong Li (Зохиогч), Zhu Guan (Зохиогч), Xinjing Tang (Зохиогч), Zhenjun Yang (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Elsevier, 2021-09-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Small interfering RNAs (siRNAs) are widely studied for their highly specific gene silencing activity. However, obstacles remain to the clinical application of siRNAs. Attaching conjugates to siRNAs can improve their stability and broaden their application, and most functional conjugates of siRNAs lo...