Feasibility of cRGD conjugation at 5'-antisense strand of siRNA by phosphodiester linkage extension

• Main Authors: Xinyang Zhou (Author), Yufei Pan (Author), Lijia Yu (Author), Jing Wu (Author), Zheng Li (Author), Huantong Li (Author), Zhu Guan (Author), Xinjing Tang (Author), Zhenjun Yang (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Small interfering RNAs (siRNAs) are widely studied for their highly specific gene silencing activity. However, obstacles remain to the clinical application of siRNAs. Attaching conjugates to siRNAs can improve their stability and broaden their application, and most functional conjugates of siRNAs lo...