LDHB Deficiency Promotes Mitochondrial Dysfunction Mediated Oxidative Stress and Neurodegeneration in Adult Mouse Brain

• Autores principales: Jun Sung Park (Autor), Kamran Saeed (Autor), Myeung Hoon Jo (Autor), Min Woo Kim (Autor), Hyeon Jin Lee (Autor), Chan-Bae Park (Autor), Gwang Lee (Autor), Myeong Ok Kim (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2022-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Age-related decline in mitochondrial function and oxidative stress plays a critical role in neurodegeneration. Lactate dehydrogenase-B (LDHB) is a glycolytic enzyme that catalyzes the conversion of lactate, an important brain energy substrate, into pyruvate. It has been reported that the LDHB patter...