LDHB Deficiency Promotes Mitochondrial Dysfunction Mediated Oxidative Stress and Neurodegeneration in Adult Mouse Brain

• Main Authors: Jun Sung Park (Author), Kamran Saeed (Author), Myeung Hoon Jo (Author), Min Woo Kim (Author), Hyeon Jin Lee (Author), Chan-Bae Park (Author), Gwang Lee (Author), Myeong Ok Kim (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Age-related decline in mitochondrial function and oxidative stress plays a critical role in neurodegeneration. Lactate dehydrogenase-B (LDHB) is a glycolytic enzyme that catalyzes the conversion of lactate, an important brain energy substrate, into pyruvate. It has been reported that the LDHB patter...