Engineering of human induced pluripotent stem cells via human artificial chromosome vectors for cell therapy and disease modeling

• Main Authors: Yasuhiro Kazuki (Author), Narumi Uno (Author), Satoshi Abe (Author), Naoyo Kajitani (Author), Kanako Kazuki (Author), Yuwna Yakura (Author), Chiaki Sawada (Author), Shuta Takata (Author), Masaki Sugawara (Author), Yuichi Nagashima (Author), Akane Okada (Author), Masaharu Hiratsuka (Author), Mitsuhiko Osaki (Author), Giulia Ferrari (Author), Francesco Saverio Tedesco (Author), Satoshi Nishikawa (Author), Ken Fukumoto (Author), Shin-ichiro Takayanagi (Author), Atsushi Kunisato (Author), Shin Kaneko (Author), Mitsuo Oshimura (Author), Kazuma Tomizuka (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Genetic engineering of induced pluripotent stem cells (iPSCs) holds great promise for gene and cell therapy as well as drug discovery. However, there are potential concerns regarding the safety and control of gene expression using conventional vectors such as viruses and plasmids. Although human art...