The effects of rabeprazole on metformin pharmacokinetics and pharmacodynamics in Chinese healthy volunteers

• 主要な著者: Guojing Liu (著者), Jiagen Wen (著者), Dong Guo (著者), Zhenmin Wang (著者), Xiaolei Hu (著者), Jie Tang (著者), Zhaoqian Liu (著者), Honghao Zhou (著者), Wei Zhang (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2016-12-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The aim was to investigate the role of rabeprazole on the pharmacokinetics (PK) and pharmacodynamics (PD) of metformin. The in vitro inhibition assays on metformin transport were carried out and showed that the half maximal inhibitory concentration (IC50) of rabeprazole on OCT2-mediated metformin tr...