Antidepressant effects of aqueous extract of saffron and its effects on CREB, P-CREB, BDNF, and VGF proteins in rat cerebellum

• Main Authors: Najmeh Asrari (Author), Rezvan Yazdian-Robati (Author), Khalil Abnous (Author), BiBi Marjan Razavi (Author), Mrazieh Rashednia (Author), Faezeh Vahdati Hasani (Author), Hossein Hosseinzadeh (Author)
• Format: Book
• Published: Korean Pharmacopuncture Institute, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective:The role of BDNF (brain-derived neurotrophic factor), CREB (cAMP response element binding) and VGF neuropeptide has been proved in antidepressant activity of long term saffron administration in the rat hippocampus. In this study we evaluated the role of these proteins in antidepressant act...