Semaphorin 3A Inhibits Inflammation in Chondrocytes under Excessive Mechanical Stress

• Main Authors: Chikako Sumi (Author), Naoto Hirose (Author), Makoto Yanoshita (Author), Mami Takano (Author), Sayuri Nishiyama (Author), Yuki Okamoto (Author), Yuki Asakawa (Author), Kotaro Tanimoto (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. Excessive mechanical stress causes inflammation and destruction of cartilage and is considered one of the cause of osteoarthritis (OA). Expression of semaphorin 3A (Sema3A), which is an axon guidance molecule, has been confirmed in chondrocytes. However, there are few reports about Sema3...