Highly Effective Non-Viral Antitumor Gene Therapy System Comprised of Biocompatible Small Plasmid Complex Particles Consisting of pDNA, Anionic Polysaccharide, and Fully Deprotected Linear Polyethylenimine

• Main Authors: Yoshiyuki Koyama (Author), Kikuya Sugiura (Author), Chieko Yoshihara (Author), Toshio Inaba (Author), Tomoko Ito (Author)
• Format: Book
• Published: MDPI AG, 2015-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have reported that ternary complexes of plasmid DNA with conventional linear polyethylenimine (l-PEI) and certain polyanions were very stably dispersed, and, with no cryoprotectant, they could be freeze-dried and re-hydrated without the loss of transfection ability. These properties enabled the p...