Lifespan analysis of brain development, gene expression and behavioral phenotypes in the Ts1Cje, Ts65Dn and Dp(16)1/Yey mouse models of Down syndrome

• Päätekijät: Nadine M. Aziz (Tekijä), Faycal Guedj (Tekijä), Jeroen L. A. Pennings (Tekijä), Jose Luis Olmos-Serrano (Tekijä), Ashley Siegel (Tekijä), Tarik F. Haydar (Tekijä), Diana W. Bianchi (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: The Company of Biologists, 2018-06-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Down syndrome (DS) results from triplication of human chromosome 21. Neuropathological hallmarks of DS include atypical central nervous system development that manifests prenatally and extends throughout life. As a result, individuals with DS exhibit cognitive and motor deficits, and have delays in...