Lifespan analysis of brain development, gene expression and behavioral phenotypes in the Ts1Cje, Ts65Dn and Dp(16)1/Yey mouse models of Down syndrome

Lifespan analysis of brain development, gene expression and behavioral phenotypes in the Ts1Cje, Ts65Dn and Dp(16)1/Yey mouse models of Down syndrome

Down syndrome (DS) results from triplication of human chromosome 21. Neuropathological hallmarks of DS include atypical central nervous system development that manifests prenatally and extends throughout life. As a result, individuals with DS exhibit cognitive and motor deficits, and have delays in...

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Main Authors: Nadine M. Aziz (Author), Faycal Guedj (Author), Jeroen L. A. Pennings (Author), Jose Luis Olmos-Serrano (Author), Ashley Siegel (Author), Tarik F. Haydar (Author), Diana W. Bianchi (Author)
Format: Book
Published: The Company of Biologists, 2018-06-01T00:00:00Z.
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