High-throughput screening of novel TFEB agonists in protecting against acetaminophen-induced liver injury in mice

• Main Authors: Xiaojuan Chao (Author), Mengwei Niu (Author), Shaogui Wang (Author), Xiaowen Ma (Author), Xiao Yang (Author), Hua Sun (Author), Xujia Hu (Author), Hua Wang (Author), Li Zhang (Author), Ruili Huang (Author), Menghang Xia (Author), Andrea Ballabio (Author), Hartmut Jaeschke (Author), Hong-Min Ni (Author), Wen-Xing Ding (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Macroautophagy (referred to as autophagy hereafter) is a major intracellular lysosomal degradation pathway that is responsible for the degradation of misfolded/damaged proteins and organelles. Previous studies showed that autophagy protects against acetaminophen (APAP)-induced injury (AILI) via sele...