Polymyxin resistance caused by large-scale genomic inversion due to IS26 intramolecular translocation in Klebsiella pneumoniae

• Main Authors: Haibin Li (Author), Lang Sun (Author), Han Qiao (Author), Zongti Sun (Author), Penghe Wang (Author), Chunyang Xie (Author), Xinxin Hu (Author), Tongying Nie (Author), Xinyi Yang (Author), Guoqing Li (Author), Youwen Zhang (Author), Xiukun Wang (Author), Zhuorong Li (Author), Jiandong Jiang (Author), Congran Li (Author), Xuefu You (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Polymyxin B and polymyxin E (colistin) are presently considered the last line of defense against human infections caused by multidrug-resistant Gram-negative organisms such as carbapenemase-producer Enterobacterales, Acinetobacter baumannii, and Klebsiella pneumoniae. Yet resistance to this last-lin...