Structural confirmation of sulconazole sulfoxide as the primary degradation product of sulconazole nitrate

• Main Authors: Qun Xu (Author), Ashraf Khan (Author), Di Gao (Author), Kristie M. Adams (Author), Fatkhulla Tadjimukhamedov (Author), Shane Tan (Author), John T. Simpson (Author)
• Format: Book
• Published: Elsevier, 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sulconazole has been reported to degrade into sulconazole sulfoxide via sulfur oxidation; however, structural characterization data was lacking and the potential formation of an N-oxide or sulfone could not be excluded. To clarify the degradation pathways and incorporate the impurity profile of sulc...