Anlotinib Inhibits PFKFB3-Driven Glycolysis in Myofibroblasts to Reverse Pulmonary Fibrosis

• Main Authors: Weimou Chen (Author), Jinming Zhang (Author), Wenshan Zhong (Author), Yuanyuan Liu (Author), Ye Lu (Author), Zhaojin Zeng (Author), Haohua Huang (Author), Xuan Wan (Author), Xiaojing Meng (Author), Fei Zou (Author), Shaoxi Cai (Author), Hangming Dong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Idiopathic pulmonary fibrosis (IPF) is a fatal disease in which the normal alveolar network is gradually replaced by fibrotic scars. Current evidence suggests that metabolic alterations correlate with myofibroblast activation in IPF. Anlotinib has been proposed to have antifibrotic effects, but the...