A monoallelic deletion of the TcCRT gene increases the attenuation of a cultured Trypanosoma cruzi strain, protecting against an in vivo virulent challenge.

• Auteurs principaux: Fernando J Sánchez-Valdéz (Auteur), Cecilia Pérez Brandán (Auteur), Galia Ramírez (Auteur), Alejandro D Uncos (Auteur), M Paola Zago (Auteur), Rubén O Cimino (Auteur), Rubén M Cardozo (Auteur), Jorge D Marco (Auteur), Arturo Ferreira (Auteur), Miguel Ángel Basombrío (Auteur)
• Format: Livre
• Publié: Public Library of Science (PLoS), 2014-02-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Trypanosoma cruzi calreticulin (TcCRT) is a virulence factor that binds complement C1, thus inhibiting the activation of the classical complement pathway and generating pro-phagocytic signals that increase parasite infectivity. In a previous work, we characterized a clonal cell line lacking one TcCR...