A monoallelic deletion of the TcCRT gene increases the attenuation of a cultured Trypanosoma cruzi strain, protecting against an in vivo virulent challenge.

• Main Authors: Fernando J Sánchez-Valdéz (Author), Cecilia Pérez Brandán (Author), Galia Ramírez (Author), Alejandro D Uncos (Author), M Paola Zago (Author), Rubén O Cimino (Author), Rubén M Cardozo (Author), Jorge D Marco (Author), Arturo Ferreira (Author), Miguel Ángel Basombrío (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trypanosoma cruzi calreticulin (TcCRT) is a virulence factor that binds complement C1, thus inhibiting the activation of the classical complement pathway and generating pro-phagocytic signals that increase parasite infectivity. In a previous work, we characterized a clonal cell line lacking one TcCR...