The calcineurin inhibitor Sarah (Nebula) exacerbates Aβ42 phenotypes in a Drosophila model of Alzheimer's disease

• Main Authors: Soojin Lee (Author), Se Min Bang (Author), Yoon Ki Hong (Author), Jang Ho Lee (Author), Haemin Jeong (Author), Seung Hwan Park (Author), Quan Feng Liu (Author), Im-Soon Lee (Author), Kyoung Sang Cho (Author)
• Format: Book
• Published: The Company of Biologists, 2016-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Expression of the Down syndrome critical region 1 (DSCR1) protein, an inhibitor of the Ca2+-dependent phosphatase calcineurin, is elevated in the brains of individuals with Down syndrome (DS) or Alzheimer's disease (AD). Although increased levels of DSCR1 were often observed to be deleterious t...