Mansonella perstans microfilaremic individuals are characterized by enhanced type 2 helper T and regulatory T and B cell subsets and dampened systemic innate and adaptive immune responses.

• Main Authors: Manuel Ritter (Author), Winston Patrick Chounna Ndongmo (Author), Abdel Jelil Njouendou (Author), Nora Nganyewo Nghochuzie (Author), Lucy Cho Nchang (Author), Dizzle Bita Tayong (Author), Kathrin Arndts (Author), Norman Nausch (Author), Marc Jacobsen (Author), Samuel Wanji (Author), Laura E Layland (Author), Achim Hoerauf (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The filarial nematode Mansonella perstans is endemic throughout Africa, northern South America and the Caribbean. Interestingly, M. perstans-infected individuals present no distinct clinical picture associated with certain pathology. Due to its relatively silent nature, research on this tropical dis...