Acetylcholinesterase inhibition protects against trastuzumab-induced cardiotoxicity through reducing multiple programmed cell death pathways

• Main Authors: Thawatchai Khuanjing (Author), Chayodom Maneechote (Author), Benjamin Ongnok (Author), Nanthip Prathumsap (Author), Apiwan Arinno (Author), Titikorn Chunchai (Author), Busarin Arunsak (Author), Siriporn C. Chattipakorn (Author), Nipon Chattipakorn (Author)
• Format: Book
• Published: BMC, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Trastuzumab (Trz)-induced cardiotoxicity (TIC) is one of the most common adverse effects of targeted anticancer agents. Although oxidative stress, inflammation, mitochondrial dysfunction, apoptosis, and ferroptosis have been identified as potential mechanisms underlying TIC, the...