The role of SIRT1 in skeletal muscle function and repair of older mice

• Main Authors: Matthew J. Myers (Author), Danielle L. Shepherd (Author), Andrya J. Durr (Author), David S. Stanton (Author), Junaith S. Mohamed (Author), John M. Hollander (Author), Stephen E. Alway (Author)
• Format: Book
• Published: Wiley, 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Sirtuin 1 (SIRT1) is a NAD+ sensitive deacetylase that has been linked to longevity and has been suggested to confer beneficial effects that counter aging‐associated deterioration. Muscle repair is dependent upon satellite cell function, which is reported to be reduced with aging...