Fumigaclavine C ameliorates dextran sulfate sodium-induced murine experimental colitis via NLRP3 inflammasome inhibition

• Main Authors: Wenjie Guo (Author), Shasha Hu (Author), Ahmed Elgehama (Author), Fenli Shao (Author), Ren Ren (Author), Wen Liu (Author), Wenjing Zhang (Author), Xinlei Wang (Author), Renxiang Tan (Author), Qiang Xu (Author), Yang Sun (Author), Ruihua Jiao (Author)
• Format: Book
• Published: Elsevier, 2015-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the present study, the effect of Fumigaclavine C, a fungal metabolite, on murine experimental colitis induced by dextran sulfate sodium (DSS) and its possible mechanism were examined in vivo and vitro. Oral administration of Fumigaclavine C dose-dependently attenuated the loss of body weight and...