Enhancing Oral Delivery of Biologics: A Non-Competitive and Cross-Reactive Anti-Leptin Receptor Nanofitin Demonstrates a Gut-Crossing Capacity in an Ex Vivo Porcine Intestinal Model

• Main Authors: Solene Masloh (Author), Anne Chevrel (Author), Maxime Culot (Author), Anaëlle Perrocheau (Author), Yogeshvar N. Kalia (Author), Samuel Frehel (Author), Rémi Gaussin (Author), Fabien Gosselet (Author), Simon Huet (Author), Magali Zeisser Labouebe (Author), Leonardo Scapozza (Author)
• Format: Book
• Published: MDPI AG, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Biotherapeutics exhibit high efficacy in targeted therapy, but their oral delivery is impeded by the harsh conditions of the gastrointestinal (GI) tract and limited intestinal absorption. This article presents a strategy to overcome the challenges of poor intestinal permeability by using a protein s...