Enhancing Oral Delivery of Biologics: A Non-Competitive and Cross-Reactive Anti-Leptin Receptor Nanofitin Demonstrates a Gut-Crossing Capacity in an Ex Vivo Porcine Intestinal Model

• Автори: Solene Masloh (Автор), Anne Chevrel (Автор), Maxime Culot (Автор), Anaëlle Perrocheau (Автор), Yogeshvar N. Kalia (Автор), Samuel Frehel (Автор), Rémi Gaussin (Автор), Fabien Gosselet (Автор), Simon Huet (Автор), Magali Zeisser Labouebe (Автор), Leonardo Scapozza (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2024-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Biotherapeutics exhibit high efficacy in targeted therapy, but their oral delivery is impeded by the harsh conditions of the gastrointestinal (GI) tract and limited intestinal absorption. This article presents a strategy to overcome the challenges of poor intestinal permeability by using a protein s...