A thrombomodulin mutation that impairs active protein C generation is detrimental in severe pneumonia-derived gram-negative sepsis (melioidosis).

• Hauptverfasser: Liesbeth M Kager (Verfasst von), W Joost Wiersinga (Verfasst von), Joris J T H Roelofs (Verfasst von), Onno J de Boer (Verfasst von), Hartmut Weiler (Verfasst von), Cornelis van 't Veer (Verfasst von), Tom van der Poll (Verfasst von)
• Format: Buch
• Veröffentlicht: Public Library of Science (PLoS), 2014-04-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

BACKGROUND: During severe (pneumo)sepsis inflammatory and coagulation pathways become activated as part of the host immune response. Thrombomodulin (TM) is involved in a range of host defense mechanisms during infection and plays a pivotal role in activation of protein C (PC) into active protein C (...