A thrombomodulin mutation that impairs active protein C generation is detrimental in severe pneumonia-derived gram-negative sepsis (melioidosis).

• Main Authors: Liesbeth M Kager (Author), W Joost Wiersinga (Author), Joris J T H Roelofs (Author), Onno J de Boer (Author), Hartmut Weiler (Author), Cornelis van 't Veer (Author), Tom van der Poll (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: During severe (pneumo)sepsis inflammatory and coagulation pathways become activated as part of the host immune response. Thrombomodulin (TM) is involved in a range of host defense mechanisms during infection and plays a pivotal role in activation of protein C (PC) into active protein C (...