A thrombomodulin mutation that impairs active protein C generation is detrimental in severe pneumonia-derived gram-negative sepsis (melioidosis).

• প্রধান লেখক: Liesbeth M Kager (লেখক), W Joost Wiersinga (লেখক), Joris J T H Roelofs (লেখক), Onno J de Boer (লেখক), Hartmut Weiler (লেখক), Cornelis van 't Veer (লেখক), Tom van der Poll (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Public Library of Science (PLoS), 2014-04-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

BACKGROUND: During severe (pneumo)sepsis inflammatory and coagulation pathways become activated as part of the host immune response. Thrombomodulin (TM) is involved in a range of host defense mechanisms during infection and plays a pivotal role in activation of protein C (PC) into active protein C (...