A thrombomodulin mutation that impairs active protein C generation is detrimental in severe pneumonia-derived gram-negative sepsis (melioidosis).

• Hoofdauteurs: Liesbeth M Kager (Auteur), W Joost Wiersinga (Auteur), Joris J T H Roelofs (Auteur), Onno J de Boer (Auteur), Hartmut Weiler (Auteur), Cornelis van 't Veer (Auteur), Tom van der Poll (Auteur)
• Formaat: Boek
• Gepubliceerd in: Public Library of Science (PLoS), 2014-04-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

BACKGROUND: During severe (pneumo)sepsis inflammatory and coagulation pathways become activated as part of the host immune response. Thrombomodulin (TM) is involved in a range of host defense mechanisms during infection and plays a pivotal role in activation of protein C (PC) into active protein C (...