Alphavirus-based hepatitis C virus therapeutic vaccines: can universal helper epitopes enhance HCV-specific cytotoxic T lymphocyte responses?

• Main Authors: Georgia Koutsoumpli (Author), Peng Peng Ip (Author), Ilona Schepel (Author), Baukje Nynke Hoogeboom (Author), Annemarie Boerma (Author), Toos Daemen (Author)
• Format: Book
• Published: SAGE Publishing, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Antigen-specific T cell immune responses play a pivotal role in resolving acute and chronic hepatitis C virus (HCV) infections. Currently, no prophylactic or therapeutic vaccines against HCV are available. We previously demonstrated the preclinical potency of therapeutic HCV vaccines bas...